Human von Willebrand factor (factor VIII-related antigen) in glial neoplastic cells of brain gliomas.
نویسندگان
چکیده
In order to determine whether the glial neoplastic cells within the brain gliomas show human von Willebrand factor (factor VIII-related antigen [FVIII-rA]) expression, and the possible distribution of FVIII-rA positive glial cells within the neoplasm, morphological examination and computerised morphometric analysis were conducted in 35 brain neoplasms, divided into 2 groups: glioblastoma multiforme (15 cases) and astrocytoma II (20 cases). Only in glioblastomas was the expression of FVIII-rA within the glial neoplastic cells found to be significantly higher than in background. The groups of FVIII-rA positive glial cells were usually found near the vascular glomeruloid structures. On the basis of the examination, the following conclusions were drawn: at least a part of the glial neoplastic cells within the glioblastoma multiforme may present expression of FVIII-rA; lack of FVIII-rA expression in the glial cells of astrocytomas II suggests that the activity of FVIII-rA within these cells is connected with the malignancy of gliomas; the role of FVIII-rA positive glial cells remains unknown, but the tendency to location near the vascular glomeruloid structures of glioblastomas might suggest their potential functional connection with endothelial cells.
منابع مشابه
Subcellular platelet factor VIII antigen and von Willebrand factor
Subcellular membrane and granule fractions derived from human platelets contain factor VIIII antigen and von Willebrand factor activity but not factor VII procoagulant activity. Circulating platelets constitute a significant reservoir of plasma factor VIII antigen, containing approximately 15% of the amount of factor VIII antigen present in platelet-poor plasma. The antibiotic ristocetin, which...
متن کاملSynthesis of von Willebrand factor by cultured human endothelial cells.
Cultured human endothelial cells synthesize and secrete a protein(s) which has Factor VIII antigen but which lacks Factor VIII clot-promoting activity (J. Clin. Invest. 52, 2757-2764, 1973). Von Willebrand factor activity has been identified in medium from cultured human endothelial cells. This activity was demonstrated by the ability to correct the defect in platelet adhesiveness of blood obta...
متن کاملSelective absence of large forms of factor VIII/von Willebrand factor in acquired von Willebrand's syndrome. Response to transfusion.
A previously healthy elderly man with mucocutaneous bleeding was found to have a benign monoclonal IgG gammapathy associated with criteria for severe von Willebrand disease (Factor VIII procoagulant activity, Factor-VIII-related antigen, and ristocetin cofactor activity, less than 10% of normal). Associated qualitative abnormalities of factor VIII/von Willebrand factor were demonstrated by radi...
متن کاملSelective Absence of Large Forms of Factor Vill/von Willebrand Factor in Acquired von Willebrand’s Syndrome. Response to Transfusion
A previously healthy elderly man with mucocutaneous bleeding was found to have a benign monoclonal lgG gammapathy associated with criteria for severe von Willebrand disease (Factor VIII procoagulant activity, Factor-VIII-related antigen, and ristocetin cofactor activity, <10% of normal). Associated qualitative abnormalities of factor VIII/von Willebrand factor were demonstrated by radiocrossed ...
متن کاملImmunohistochemical Localization of Factor Viii-related Antigen in Human Endothelial Cells
Immunohistochemical localization of factor VIII-related antigen was studied in human tissues obtained at autopsy or renal biopsy, umbilical cord vessels, smears of washed blood cells and cultured human endothelial cells. Factor VIII-related antigen was demonstrated in the vascular intima throughout the body and cells lining the sinusoids of the lymph node, spleen and liver by an indirect immuno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Folia neuropathologica
دوره 41 1 شماره
صفحات -
تاریخ انتشار 2003